Solving for Brainpower: How Puzzles Boost Cognition at Every Age – With Insights from Dr Gregory Duhon, MD

Originally published on Curious Mind Magazine

Whether it’s the quiet satisfaction of snapping in a final jigsaw piece or the triumphant rush of solving Saturday’s crossword, puzzles offer more than entertainment—they’re workouts for the mind. From sharpening memory to improving attention span, a growing body of research suggests that puzzles stimulate the neural machinery that keeps us mentally fit at every stage of life.

The Neuroscience of the Puzzle Habit

When we decode clues or rotate puzzle pieces into place, multiple areas of the brain light up in synchrony. Neuroimaging studies show that the prefrontal cortex and hippocampus—regions critical to memory and reasoning—activate intensely during problem-solving. In Frontiers in Aging Neuroscience, researchers found that sustained engagement in complex puzzles strengthens the brain’s cognitive reserve—its ability to adapt and maintain function as we age (Frontiers, 2018).

“It’s fascinating how something as simple as a crossword can light up the same regions we rely on in medicine,” says Dr. Gregory Duhon, MD, an Internal Medicine Physician and Hospitalist known for his work in ICU and crisis management. “You’re pulling patterns from memory, testing logic, and exercising patience—all skills that translate directly into real-world decision-making.”

Sharper Memory, Stronger Focus

A large-scale study by the University of Exeter and King’s College London followed more than 19,000 adults and found that those who regularly solved crosswords or number puzzles performed significantly better on tests of memory, reasoning, and attention. Frequent puzzle solvers displayed cognitive abilities comparable to people up to ten years younger (University of Exeter, 2019).

“Attention is a muscle,” notes Dr. Duhon. “When I work through a crossword clue, I can feel my focus narrow—it’s the same sense of mental stillness I need in an ICU, where missing one small detail could change everything.”

That immersive focus is what psychologists call flow—a meditative, hyper-engaged state that reduces stress and enhances performance. It’s the mental “sweet spot” where your skills are stretched just enough to keep you fully engaged. Studies show that when people reach this state, they make fewer mistakes and can stay focused for longer periods (Psychological Research). Brain imaging research also suggests that during flow, the mind becomes better at tuning out distractions—like background noise or wandering thoughts—so it can give full attention to the task at hand (Comprehensive Psychology).

“That’s one reason puzzles are such powerful brain boosters,” explains Gregory Duhon. “They draw you into that same focused zone, helping train your mind to concentrate more easily and block out mental clutter—even after you’ve set the puzzle aside.

Puzzles and Cognitive Longevity

While puzzles alone can’t prevent cognitive decline, they form part of a broader pattern of lifelong learning linked to better brain health. “What’s powerful about puzzles is not that they’re magic bullets,” Dr. Duhon explains, “but that they remind us the brain wants to be used. It thrives on novelty and challenge.”

The Alzheimer’s Association likewise encourages mentally stimulating activities—particularly those that demand reasoning or problem-solving—as one component of maintaining cognitive vitality, alongside physical activity, quality sleep, and social engagement.

Emerging research is also exploring puzzles as digital biomarkers for cognitive change. In one study, scientists developed maze-like games to measure executive and visuospatial abilities, finding a strong correlation between gameplay performance and cognitive health (Frontiers, 2020).

The Joy of Solving

Puzzles ask us to linger with uncertainty—to try, fail, and try again. In that process lies a subtle lesson in patience and persistence. “There’s something humbling about realizing a crossword clue won’t yield right away,” says Dr. Duhon with a laugh. “But that’s when the brain really wakes up—it’s solving, not knowing, that keeps us sharp.”

Each solved clue or placed piece is a small act of mindfulness, a reminder that progress often comes one insight at a time. And as neuroscience increasingly affirms, those small moments of problem-solving may add up—nurturing a more adaptable, resilient, and vibrant mind at any age.

About Dr Gregory Duhon, MD

Dr. Gregory Duhon, MD, is an Internal Medicine Physician and Hospitalist with acumen in ICU, emergency room, and crisis/pandemic management. Known for compassionate patient care, Dr. Duhon has donated volunteer time to provide medical care to flood victims and those affected by opioid addiction. Gregory Duhon is training for the Ironman and enjoys travel, cooking, and passion fruit propagation.